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412 Therefore, more rigorous clinical trials are needed before approval can be obtained

Despite a strong mechanistic and preclinical foundation, the clinical application of luteolin has been limited by its poor aqueous solubility, extensive phase II conjugation, and low oral bioavailability (Wang et al., 2024

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There may be risk

Intestinal inflammation, dysbiosis, or increased permeability can significantly reduce DAO production and allow dietary histamine to enter circulation unchecked