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Evidence supports several interventions: Cognitive behavioral therapy (CBT) : Randomized controlled trials demonstrate that CBT specifically designed for menopausal symptoms reduces hot flash-related distress and improves quality of life, even when frequency remains unchanged [35] [36] Clinical hypnosis : Studies show significant reductions in hot flash frequency and interference with daily activities [40] Weight management : Obesity correlates with increased hot flash severity

doi: 10.1023/A:1018863716749 160 SchirraJHouckPWankUArnoldRGkeBKatschinskiM

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Model building and refinement The structures of the LSN3160440GLP-1GLP-1RG s (PDB: 6VCB), GLP-1GLP1RG s (PDB: 6X18) and RGT1383GLP-1RG s (PDB: 6B3J) were used as an initial template for model building of compound 2, compound 2 plus GLP-1, and compound 2 plus LY3502970 bound complexes, respectively