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Overexpression of IGF-IR in prostate cancer is associated with high Gleason grade and increased risk of tumor recurrence and metastasis [41]

Affecting hemodynamics In infectious acute kidney injury, necrotic cell-derived DNA induces platelet activation and platelet-granulocyte interactions, which subsequently promote NET formation, thereby exacerbating renal inflammation and tissue injury [279, 322]

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Mechanisms of glucocorticoid receptor signaling during inflammation

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