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[DOI] [PubMed] [Google Scholar] Matera M., Bellinghieri G., Costantino G., Santoro D., Calvani M., Savica V

But none of us should settle for inadequate rest, because our health takes a hit: Poor sleep is associated with increased risk of coronary heart disease, osteoporosis, and decreased cognitive function, as well as overall mortality

IECs turn over completely every three to five days, making them highly dependent on efficient growth factor signaling and adequate ECM scaffolding

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The connection runs through immune function and inflammation

It represents a precautionary approach given limited long-term data rather than a response to documented concerns