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This dual-agonist mechanism produces more potent effects on appetite suppression, insulin sensitivity, and fat metabolism than GLP-1 agonism alone

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The primary endpoints were the change in body weight and the proportions of patients losing at least 5% and 10% of their initial body weight

The progression from single-agonist to dual-agonist and now triple-agonist therapies reflects our growing understanding of the complex hormonal systems that regulate weight and metabolism

Patients in the semaglutide groups also had dose dependent reductions in HgA1c, liver tests, hepatic stiffness values (based on transient elastography), and body weight (13% in the semaglutide 0.4mg group vs 1% in placebo) at 72 weeks