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Role of oncometabolites in modulating the epigenetic landscape of cancer cells Concerning the epigenetic alterations associated with oncometabolites, it has been shown that D-2HG accumulation, an event that is coupled with -KG depletion, inhibits histone lysine demethylases (KDMs), giving rise to histone hypermethylation, epigenetic programming, and acquisition of additional mutations [27]

Cold Spring Harbor Perspect Biol 14(3):a041012 Funding Open access publishing supported by the institutions participating in the CzechELib Transformative Agreement

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Mark the reconstitution date on the vial