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In August 2025, semaglutide (Wegovy) received FDA accelerated approval for MASH with F2 to F3 fibrosis based on the results of the ESSENCE trial

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In line, the down regulation of miR-132 was found to inhibit the level of hippocampal acetylcholinesterase (AChE) , impacting both cognitive function and synaptic plasticity

Incretin-based drugs and the risk of gallbladder or biliary tract diseases among patients with type 2 diabetes across categories of BMI: a nationwide cohort study

1 Theres no head-to-head comparison with Mounjaro or Wegovy, so the differences between the trials should be read with caution

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