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This increased cAMP activates PKA which in turn promotes insulin synthesis and secretion and inhibits glucagon release (Yang and Yang, 2016)

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Figure 2: Biological Efficacy Metrics Clinical Efficacy & Key Findings Outcome 1: Demonstrates up to 15% mean body weight reduction in prolonged studies

Currently, 25% of adults in the United Kingdom are living with obesity and the rise in obesity has significantly increased the number of patients with T2DM [4,5,6]

For women using oral contraceptives, effectiveness may be reduced during tirzepatide initiation and dose escalation