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B12 is essential for red blood cell production, neurological function, and cellular energy metabolism

It differs structurally from native IGF-1 in two ways: an arginine substitution for glutamic acid at position 3 (the R3), and an additional 13-amino-acid extension at the N-terminus (the Long)

Data availability The datasets supporting the conclusions of this article are included within the article and its supplementary files

We found that Gclc ablation prevented the formation of T1 B cells by 2 weeks of age, indicating that a block in the B cell differentiation process occurred at the very early stage in the spleen (Fig

Nature 413 , 591596 (2001)

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