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The reduction in hepatic steatosis occurred alongside improvements in liver enzymes, with ALT and AST levels declining from baseline, indicating reduced hepatocellular inflammation and improved liver health

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Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions

For some, the dual-agonist mechanism of Mounjaro provides the perfect balance of efficacy and tolerability, while others may find the single-agonist Wegovy 7.2mg dose, introduced on January 12, 2026, more suitable for their specific metabolic architecture