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10.1038/cr.2016.95 47 GaoM.MonianP.QuadriN.RamasamyR.JiangX

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The reason is straightforward: tendons and ligaments have poor native blood supply, which means they heal slowly under the best circumstances and often stop progressing entirely after initial recovery

Graf and Kastin documented that DSIP affects not just sleep itself but the neuroendocrine systems that govern sleep including ACTH, growth hormone release patterns, and circadian oscillators (Graf & Kastin, 1984)