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Vitamin B12 is a water-soluble vitamin, meaning any remaining amount that your body cant use leaves your body through your urine

Semaglutide, Tirzepatide, and Retatrutide all fall into this category, though each generation adds more receptor targets

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

This is rare, but better to be safe

First, it should not be done on your own

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