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& Rorsman, P
The warning letters flagged specific violations: claims of "same active ingredients" as brand-name drugs, language implying therapeutic equivalence, use of "clinically proven" phrasing, and statements implying FDA approval of compounded products
Retatrutide research remains in earlier stages, with most long-term data still being gathered
As for Polyphenol Booster, it contains: Pomegranate extract (375mg) , shown in a 2022 study to increase short-chain fatty acids and regulate GLP-1 secretion at 375mg doses,32 while a 2025 study found that pomegranate in general can help proliferate beneficial bacteria, including Akkermansia 33 Grape seed extract (275mg) , which produces a significant prebiotic effect on Akkermansia , as in a 2021 study that used 200mg doses34 Green tea extract (225mg) , which also favors Akkermansia proliferation,35 potentially at doses as low as around 50mg in a 150lb human (as suggested by mouse studies)36 All very well-dosed to support Pendulums probiotic supplements
All authors reviewed and approved the final version of the manuscript
W., Pietersma, K
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