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Gene expression signatures of C1-27 and GSTO1 knockdown To identify pathways regulated by GSTO1 and to understand the mechanism of its antiproliferative effects, we used the nascent RNA Bru-seq method 27 to profile gene expression changes that occur in response to GSTO1 knockdown and inhibition

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592,593 Moreover, due to the decrease of 3-hydroxykynurenine (a cytotoxic metabolite of KMO), the mice that lack active kynurenine 3-monooxygenase (KMO) will not develop into AKI after I/R injury