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First, diabetes blunts weight loss by roughly 6 to 7 percentage points versus non-diabetic obesity at the same dose, because long-standing high glucose dampens the metabolic cascade the drug works through. Second, the 10-to-15 mg step keeps adding weight loss in every band

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In its Thursday advisory, the agency says it's "working with the Canada Border Services Agency to stop unauthorized shipments from entering the country." CBC News has reached out to Health Canada for further comment.