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This is likely due to it being endogenously synthesized all throughout the body and it is basically found in all cells, sometimes in rather high concentrations
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Convincing evidence that GLP-1R stimulating drugs are associated with anti-inflammatory, neurotrophic, and neuroprotective properties in preclinical models of NDD has led to trials of these drugs in the NDD clinic
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Also of concern is the possibility of Stevens Johnson Syndrome
In a 2023 Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al.), retatrutide produced 22.8% to 24.2% mean weight loss at 48 weeks at the higher doses (8 to 12 mg)
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