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A deficiency of acid phosphatase activity in the lysosomal fraction, presumably due to impairment of the ACP2 protein, manifests as intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding and death in early infancy (136)

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A similar conclusion was reached in a network meta-analysis which demonstrated an increased odds ratio for clinical pregnancy following surgical laparoscopy compared with placebo (OR 1.63

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Activation of the cellular antioxidant machinery (HO-1, glutamate-cysteine ligase catalytic subunit and Nrf2) resulted in SFN-mediated protection against memory impairment in rats treated with okadaic acid [69]

However, its low pH requirement (2.5-3.5) makes it the most problematic for direct peptide layering