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During the fasting state, GH-secretion from the pituitary glands is markedly stimulated, whereas insulin and IGF-1 secretion is reduced

Dose increase: at Day 16 inside the on phase, the dose steps from the low end to the high end of the range

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GLP-1 RA therapy reduces the risk of incident atrial fibrillation by 46% in patients with HFpEF and HFmrEF while also improving weight, blood pressure, and left atrial remodeling

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