This process is mediated through the nucleotide-binding pocket within the subunit, where AMP competitively inhibits ATP binding and enhances kinase activity (Trefts and Shaw, 2021)
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These differences are likely to reflect monovalent binding of Fab compared with divalent binding of whole IgG, depending upon the spacing of targeted epitopes on the virion surface 94,95,96
Even a single amino acid substitution can dramatically alter the peptide's properties and render it ineffective