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The medication shares approximately 94% structural homology with human GLP-1 but incorporates strategic molecular modifications that dramatically extend its duration of action

It also means cagrilintide could potentially be an option for people who dont respond well to GLP-1-based medications, or who experience side effects that make GLP-1 drugs hard to tolerate

It works best when combined with a healthy diet and exercise routine

Experts say there are plausible albeit unconfirmed explanations, noting for example that GLP-1 medications may interfere with the efficacy of oral contraceptives or increase fertility in women because they help with weight loss

Lilleri et al, 2016), it is tempting to speculate that gp34 may be involved in this attenuation of humoral immunity