This includes people with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
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The pattern observed in TRIUMPH-4: 2 mg: ~13% mean weight loss 4 mg: ~17% mean weight loss 8 mg: ~24% mean weight loss 12 mg: ~28.7% mean weight loss This positions retatrutide as the first agent capable of routinely producing weight loss greater than 25% territory previously reached only by bariatric surgery
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Similarly, both exenatide extended-release and liraglutide had large variabilities between subjects compared to semaglutide [10, 11]