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For example, data indicate that slightly more than half of patients with T2DM meet the general hemoglobin A1C goal of less than 7%, and suboptimal glycemic control continues to contribute to the development of complications like cardiovascular disease and microvascular complications
Moreover, increased proximal tubular glucose reabsorption disrupts normal tubuloglomerular feedback, further amplifying intraglomerular pressures [25]
Orforglipron Pending Approval - An experimental oral GLP-1 receptor agonist in clinical trials
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Higher targets can be appropriate in cases of limited life expectancy, advanced complications or poor tolerability or if other factors such as frailty are present
