tirzepatide and osa Diabetes & Weight Loss Drug Now Approved for (Obstructive Sleep Apnea) In the two SURMOUNT-OSA trials,

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Study outcomes According to the treatment-regimen estimand, adults receiving orforglipron 12 mg had a 1.71 percentage point decline in HbA1c, and those receiving orforglipron 36 mg had a 1.91 percentage point drop in HbA1c at 1 year compared with a 1.23 percentage point reduction with semaglutide 7 mg and a 1.47 percentage point decrease with semaglutide 14 mg

Strength of recommendation: 2C Rationale: Low-dose aspirin (75100mg/day) should be prescribed for secondary prevention of atherosclerotic cardiovascular disease among patients with diabetes and CKD and atherosclerotic cardiovascular disease, according to all guidelines and the available evidence.104108 The recent post hoc analysis of the ADAPTABLE trial among the subset of patients with diabetes showed that there were no differences in terms of efficacy and safety of low dose (81mg/day vs