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Additionally, vitamin E may not be biologically important as an AT, but rather as a signaling molecule and regulator of specific gene expressions ( Various structurally related derivatives of vitamin E have been developed, some of which have improved antioxidant effects with in vitro AT assays or animal models

doi:10.1038/oby.2008.56

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These discoveries align with the findings of our investigation about the histological alterations observed in gentamicin-induced acute renal failure