PT-141 is a melanocortin receptor agonist, it acts on receptors in the brains motivational and desire pathways rather than on sex hormones or blood flow
Weger, M
Over the last 5 to 10 years, peptides have gone from something only performance athletes, biohackers, and longevity doctors talked about to something you hear about casually in group chats and on TikTok
Its main function is to transport long-chain fatty acids into the cells, where they can be metabolised to produce energy
It downregulates the gene and protein expression of COX1, 5-LOX, 12-LOX, and 15-LOX in the arachidonic acid pathway, restores the levels of abnormal metabolites such as PGE2, PGD2, LTB4, 12-HETE, 15-HETE, PGF2, and 8-iso-PGF2 in PAH models, inhibits abnormal proliferation of PASMCs, and reverses pulmonary vascular remodeling (Song et al., 2022)
This is not a contraindication, but it is a monitoring consideration that differs from adding a standard oral vitamin