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Effect of study bias, publication bias, and small-study effects In all analyses, the pooled estimated SMDs for the subgroups of studies deemed to have low bias was within the 95% CI of the overall (Table 4), suggesting the impact of studies with higher bias was small
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ROC analysis was conducted using three external datasets GSE23339, GSE6364, GSE51981 to demonstrating the significance of our prediction model in diagnosing the disease in EMs relative to normal groups
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For example, a meta-analysis revealed the following changes when comparing GLP-1 agonists to placebo: Waist circumference dropped by 5.16 cm BMI decreased by 2.42 kg/m Triglycerides were reduced by 0.20 mmol/L Total testosterone levels fell by 1.33 ng/mL The reduction in waist circumference is particularly impactful because visceral fat is metabolically active and worsens insulin resistance
