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For viral genome cyclization during WNV RNA synthesis and replication, the nonstructural viral protein NS5 requires assistance from the host factor AU-rich element-binding protein 1 (AUF1) isoform p45 [163]

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Their pleiotropic effects, which range from anti-inflammatory, antioxidant, and metabolic regulation to neuroprotective and endothelial-stabilizing properties, are mediated through complex intracellular pathways, including the PI3K/Akt, AMPK, and NF-B signaling pathways

Anticancer Res 37 , 39833990 (2017)