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We need to think about creative alternative weight maintenance strategies to provide a whole obesity chronic care model, Kim said

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For example, liraglutide, though also effective, typically results in somewhat lower overall weight loss than semaglutide, with dulaglutide and exenatide demonstrating similarly modest outcomes by comparison

The baseline HbA1c in the tirzepatide arms was 8.23%8.36% and 8.37% in the placebo group

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We think GLP-1s may shut down the ability for stem cells in dermal white adipose tissue, a thin layer of fat beneath the skin, to signal fibroblasts to produce collagen and elastin, says Steven Dayan, MD, a plastic surgeon in Chicago who has co-authored research papers on GLP-1s aesthetic side effects