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SARS-CoV-2 infections are also associated with higher profibrotic dipeptidyl peptidase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK - adenosine monophosphate-activated protein kinase) activation in kidney cells

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Given that large, long-duration studies may be needed to demonstrate that a disease-modifying therapy is engaging the intended target and modifying disease progression, biomarkers can play an important role in phase 2 clinical trials to demonstrate proof of concept prior to initiating trials intended to demonstrate clinical benefit (Cummings, 2019

Human RAMPs were modified with an N-terminal Flag tag epitope

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