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Trial NCT01845220 aimed at evaluating the effect of SFN (as BS extract) exposure in alcohol-intolerant subjects

Why is this important

These reactive molecules can interact with various cellular components, leading to cellular damage and various pathological changes

For example, once microglial cells in spinal cord were activated by sciatic nerve injury, minocycline could not inhibit the neuropathic pain (Akimoto et al., unpublished data)

As with any IV, rare risks include allergic reactions, infection, vein irritation, or electrolyte issues

Biochemical changes : Caused significant liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes ALT, AST, ALP, and GT