Transgenic mice specifically overexpressing IGF-1 in mammary epithelium demonstrate upregulation of the Vascular Endothelial Growth Factor (VEGF), a pro-angiogenic factor, in prepubertal glands and induction of cyclooxygenase-2 (COX-2), an inflammatory molecule that is also associated with angiogenesis and is responsible for formation of prostaglandin (PG), [55]
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Biomedecine Pharmacother
Ethics declarations Competing interests M.M.V., S.C.L., L.A., R.K., S.S., Y.C., B.W., J.R.F., T.H., V.A.T., M.A., L.S., Y.Z., V.K., R.J., R.K.O., J.R.P., N.H
It enhances glucose-dependent insulin secretion, inhibits glucagon release, slows gastric emptying, and suppresses appetite via central nervous system pathways (Milder et al
Most DSIP research has been conducted in animals