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They significantly decrease markers of oxidative stress (ROS, NO) and inflammation ( TNF- , IL-1 ), while modulating pathways involved in lipid metabolism ( PPAR- ) and antioxidant defense ( HO-1 , Nrf2 ), with the latter extract specifically shown to suppress the TLR4/MyD88/NF-B signaling pathway (Gao T

PMID: 30356415

doi: 10.1002/ar.25148 47

^ Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

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This was also observed in this study in the magnesium treated group with values obtained being comparable to those of the insulin treated animals (Figure 1)