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During myocardial reperfusion following ischemia, the production of oxygen free radicals increases dramatically, disrupting oxidative balance and antioxidant defense systems, leading to cellular damage and abnormal immune responses ( Mitochondrial dysfunction is a hallmark of myocardial I/R injury, with impaired mitochondrial quality control serving as a critical factor in arrhythmia development (Tu et al., 2013)
N Engl J Med 342(3):154160
The pharmacokinetic profile of liraglutide, which makes it suitable for once-daily administration, is a result of self-association that delays absorption, plasma protein binding, and stability against metabolic degradation by DPP-4 and NEP
ZL: Software, Writingoriginal draft
Generally, most reconstituted peptides remain stable and potent for about 4 to 5 weeks when stored correctly
[PMID: 36136154]
