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Enzyme-replacement therapy in life-threatening hypophosphatasia

Most notably, the annual incidence of acute pancreatitis was reduced by 85% in the pooled olezarsen groups versus placebo (rate ratio 0.15, 95% CI 0.050.40), with a particularly marked benefit in patients at highest risk

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In breast cancer, particularly in TNBC, HIF-1 binds to the VEGF promoter directly and activates VEGF transcription (115)

The medication makes you feel full earlier and for a longer time by promoting a feeling of satiety