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While animal studies (specifically in rodents) showed an increased risk of medullary thyroid cancer, human studies and large-scale clinical trials have not yet demonstrated a significant link

The SURMOUNT-5 trial , as described by Aronne and colleagues, compared tirzepatide (Zepbound) to semaglutide (Wegovy), a mono GLP-1, in 751 adults living with obesity with one weight-related medical issue but without diabetes

Eur Respir J 2000;16(2):253-62

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