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Research into ferroptosis in liver disease is predominantly focused on the regulation of oxidative stress, focusing on hepatocellular carcinoma and drug-induced liver injury

10.1002/biof.5520100102 53 FitzgeraldK.MikalunasV.RubinH.McCartheyR.VanagunasA.CraigR

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Clarifying the stages at which these pathways contribute to the inflammatory phenotype and identifying the cell types orchestrating this inflammasome-independent response are crucial areas for further investigation

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Like metformin, acarbose is effective as a first-line drug for type 2 diabetes insufficiently controlled by diet alone, and does not stimulate insulin secretion or cause hypoglycemia or weight gain