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The Dual Agonist Advantage: GLP-1 and GIP Unlike earlier medications that targeted only one pathway, tirzepatide is a novel dual agonist, mimicking the action of two naturally occurring incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

doi: 10.1016/j.ncl.2008.07.003 48 HoriMConnollySJZhuJLiuLSLauCPPaisPet al

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It is possible that this relatively selective colonic mucosal involvement may reflect the qualitative or quantitative differences in colonic microbial flora (as opposed to the small intestine)

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