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In rodent models, the compound has been shown to increase GH pulse amplitude without significantly altering pulse frequency a finding of relevance to endocrine rhythm research

doi: 10.4149/BLL_2023_029 68 ChaoGZhuYFangL

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By activating GLP-1 receptors, Tirzepatide helps to increase insulin secretion, decrease glucagon secretion, slow down gastric emptying, and promote satiety

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LD, AW, SB and MV performed the in vivo data curation, while JC and PL conducted the spatial transcriptomics analyses