Lancet Oncol 23 (11): 1378-1388, 2022
Of note, whereas drug adverse effects may emerge early because of the sudden exposure of the body to a new substance, adverse effects tend to be clearly present only when a critical threshold, usually related to blood level, is reached
Metabolism & Elimination GLP2 undergoes metabolism through pathways typical of peptide therapeutics: Plasma half-life of approximately 5 days in humans, enabling once-weekly administration Primary metabolic pathways include proteolytic cleavage of the peptide backbone, beta-oxidation of the C20 fatty diacid moiety, and amide hydrolysis Not metabolized via cytochrome P450 enzymes, sulfation, or glucuronidation pathways Low potential for drug-drug interactions mediated through hepatic metabolism or transporter systems The extended half-life represents a key pharmacokinetic advantage, with steady-state accumulation of approximately 1.7-fold enabling consistent therapeutic exposure throughout the dosing interval
If you are anything like me, when I see a sulfa allergy, the first thing I think of is Bactrim (which contains sulfamethoxazole)
[PMC free article: PMC3793633] [PubMed: 23599441] 329
Greco, G