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Pharmacokinetic Parameters Estimates of pharmacokinetic parameters are presented in Table 3

Realistic expectations are 0.25-0.5 kg (0.5-1 lb) per week under optimal conditions, with the rate influenced by baseline body composition, dietary habits, activity level, and individual metabolic responsiveness

doi:10.1001/archpsyc.62.11.1266CrossRefGoogle Scholar Sturman, N, Deckx, L, van Driel, ML

According to FDA labeling, no dose adjustment is required for patients with renal impairment, including those with end-stage renal disease

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