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Evinacumab for pediatric patients with homozygous familial hypercholesterolemia

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Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)

Traumatic brain injury is an increasingly recognized cause of AGHD and may occur without coexisting deficiencies in other anterior pituitary hormones (27)

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