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Two independent reviewers conducted the risk of bias assessment in a prespecified sequence, evaluating selection, performance, detection, attrition, and reporting bias domains in order

Stress conditions activate mast cells to release prestored and newly synthesized inflammatory mediators and induce increased blood-brain barrier permeability, recruitment of immune and inflammatory cells into the brain and neuroinflammation

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Furthermore, objective testing showed that intestinal permeability (measured by urinary lactulose/mannitol ratios) was completely normalized in the glutamine group, proving its direct barrier-healing capabilities

The role of necroptosis in atherosclerotic disease