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Type 1 is the enzyme variant primarily responsible for converting testosterone to DHT in hair-damaging locations, and this inhibition occurs with greater specificity for the hair-relevant type 1 than the prostate-relevant type 2

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Mice without injected STZ were set as a Negative control group

In the proposed mechanism, xylitol induces Bip and CHAC1, resulting in decreased cellular GSH levels, ER stress, and ultimately apoptotic cell death