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Surface expression of Syt1 pHluorin was assessed by measuring the fraction of Syt1 pHluorin on the cell surface, with fluorescence normalized to 1 in NH 4 Cl buffer and 0 in acidic buffer

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Mazdutide is a dual GLP-1/glucagon agonist developed by Innovent Biologics, primarily studied in Chinese populations, showing weight loss of 14-18% in clinical trials