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Clinical Takeaway: GLP-1s dont just reshape the bodythey may support the mind, too

A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

Role of nitric oxide in the cardiovascular and renal systems

The SELECT trial builds on these results, showing that once-weekly semaglutide resulted in a 20% reduction in the primary composite endpoint of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with pre-existing cardiovascular disease and BMI 27kg/m 2

further protecting vascular health

The homogenate was vortexed for 30 min to ensure complete homogenization