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No Phase I, II, or III trial has been completed and published in a peer-reviewed journal with systematic adverse-event reporting

Not worth the risks, though

Similar counteraction of severe muscle weakness occurred in rats with abdominal aorta anastomosis, marked attenuation of the vessel obstruction (early regimen), and full annihilation of the obstructing thrombus (late regimen) [129]

This ensures the treatment is safe and effective

In fact, its been found that B12 supplements taken orally are just as effective as intramuscular shots in overcoming states of deficiency when you take up to 1,000 micrograms a day

The answer often comes down to peptide vs GLP-1 mechanism