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Furthermore, since T-cells are actively recruited into the brain during a pro-inflammatory response, astrocytes modulate the anti-inflammatory response by activating the TNF-related apoptosis-inducing ligand (TRAIL) (Sanmarco et al., 2021)

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Two additional enzymes of folate metabolism, aldehyde dehydrogenase 1 family member L1 (encoded by the ALDH1L1 gene) and ALDH1L2, produce NADPH in the course of converting N 10 -formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate (THF) and CO 2

Glutathione comprises three different amino acids: cysteine, glutamic acid, and glycine