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Similarly, dysregulated phosphatidylinositol 3-kinase (PI3K)/AKT signaling is associated with obesity and insulin resistance (Li et al

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Musculoskeletal causes include arthritis affecting weight-bearing joints, postural strain from prolonged sitting, and muscle overuse, while visceral sources involve digestive disorders like IBS or kidney dysfunction

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Andersen JV (2025) The glutamate/GABAglutamine cycle: insights, updates, and advances