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The relevant clinical conversation, when it becomes one, is for patients who plateau on existing therapy or who would otherwise be candidates for bariatric surgery a population for whom retatrutide's responder rates start to look like a genuine alternative

What Should Patients and Healthcare Professionals Know

Thayer JF, Yamamoto SS, Brosschot JF

Key Takeaways Agonism Profile: Tirzepatide is a dual GLP-1/GIP agonist, while Retatrutide is a "triple agonist" targeting GLP-1, GIP, and Glucagon receptors

What weight-loss results did retatrutide show in trials