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Inflammatory pathways in the body have been proven to be modulated by polyphenols, which help to lessen chronic inflammation, which is linked to a number of diseases like heart disease, obesity, and some types of cancer

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This was reported by Pax et al

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Preclinical Evidence for Serotonergic Changes Animal studies published in Neuropharmacology (2005) demonstrated that isotretinoin administration in mice significantly reduced serotonin transporter (SERT) binding in the frontal cortex and hippocampus, suggesting altered serotonin reuptake dynamics at clinically relevant doses

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